Shu-Jen Wu was born in Taiwan in 1958. She studied at the Art Institute of Missouri State University, the Art Department of SUNY Stony Brook, and the Fine Arts Department of Chinese Painting at the National Taiwan University of Arts. She has served as the cultural director of New Jersey's Fidelity Chinese School and taught students Chinese painting and calligraphy. She has won many awards from the Arts Society of Monmouth County, New Jersey, and has held solo exhibitions at SUNY Stony Brook, Kansas City Community College, New Jersey community schools, and Monmouth County Library.

In April 2019, her work was selected to be part of a museum exhibition at Taiwan's National Chiang Kai-Shek Memorial Hall. The exhibition served to showcase the best artists who had once studied under the legendary painter, Li Qimao. Wu works with inks, oils, acrylics, and watercolors in a diverse spectrum of styles that range from classical Chinese, still life, impressionism, abstract, and a unique fusion that aims to bring out the spirit of classical Chinese paintings using the methods of contemporary abstract art.